Survodutide (BI 456906)
Survodutide (internally designated as BI 456906) is a novel, long-acting synthetic peptide that functions as a dual agonist for both the Glucagon-Like Peptide-1 (GLP-1) receptor and the Glucagon receptor (GCGR). In the field of advanced metabolic research, Survodutide represents a significant evolution in multi-receptor pharmacology. By simultaneously activating the GLP-1 pathway to improve insulin secretion and suppress appetite, while engaging the Glucagon receptor to increase energy expenditure and facilitate hepatic lipid mobilization, this compound provides researchers with a high-precision tool to study complex weight management and metabolic regulation mechanisms.
Our Survodutide is synthesized in an ISO 9001:2015 certified and GMP-grade manufacturing environment. Utilizing state-of-the-art solid-phase synthesis and multi-stage HPLC purification, we achieve a chemical purity of ≥99%. This meticulous standard ensures that the peptide is free from truncated isomers and residual chemical reagents, guaranteeing the consistency and reliability required for sensitive in-vitro assays and longitudinal metabolic microenvironment studies.
Research Applications & Mechanisms
Dual Receptor Synergy
Investigating the “dual-target” approach to metabolic signaling, focusing on the balance between incretin-mediated insulin sensitivity and glucagon-mediated thermogenesis.
MASH & Hepatic Research
Researching the influence of GCGR activation on hepatic fat oxidation and its potential in studies involving Metabolic Dysfunction-Associated Steatohepatitis (MASH).
Energy Expenditure Pathways
Studying the molecular pathways through which Survodutide modulates basal metabolic rate and lipolysis in experimental adipocyte models.
Glycemic Control Homeostasis
Exploring the combined effects of dual agonism on postprandial glucose regulation and long-term glucose-sensing mechanisms within the pancreas.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | Survodutide (BI 456906) |
| Agonist Type | Dual GLP-1R / GCGR Agonist |
| Production Quality | GMP-Level Compliance |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Solubility | Highly Soluble in Water / Bacteriostatic Water |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the Survodutide powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure optimizes reconstitution and protects the sensitive peptide chains from oxidative degradation.
High-Fidelity Synthesis
Every batch undergoes strict Mass Spectrometry (MS) to confirm sequence identity and HPLC to verify that purity levels exceed research requirements, ensuring no interference in receptor binding assays.
Reconstitution & Storage
Reconstitution Guide
-
Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the Survodutide cake is at the base.
-
Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.
-
Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
-
Long-term: Store at -20°C (Maintains potency for up to 24 months).
-
Short-term: Stable at 2–8°C for up to 3 months.
-
Post-Reconstitution: Store at 2–8°C and utilize within 7-14 days for optimal results.
Shipping & Documentation
-
Global Logistics: Shipped in discreet, temperature-controlled packaging to protect the Survodutide molecular integrity.
-
Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
-
Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This Survodutide (BI 456906) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
-
PubMed – NIH: Clinical and preclinical research on Survodutide (BI 456906) GLP-1/glucagon receptor dual agonist
-
ScienceDirect (Elsevier): Peer-reviewed Research on GLP-1/Glucagon Dual Agonists
🔍 Deep Dive Research
-
[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
-
[Metabolic Study]: The Dual Mechanism: GLP-1 and Glucagon Synergy in Adipocyte Research
MadMatt –
Product looks accurate.