SS-31 (Elamipretide)
SS-31, also known as Elamipretide, is a first-in-class synthetic tetrapeptide (D-Arg-2′,6′-dimethyl-Tyr-Lys-Phe-NH2) that specifically targets the inner mitochondrial membrane. Unlike general antioxidants, SS-31 selectively binds to cardiolipin, a unique phospholipid essential for mitochondrial cristae structure and electron transport chain function. In advanced biochemical research, SS-31 is a primary focus for investigating the restoration of mitochondrial bioenergetics, the reduction of mitochondrial reactive oxygen species (ROS), and the prevention of cytochrome c release. It provides researchers with a highly stable tool to study cellular rejuvenation in models of aging, neurodegeneration, and metabolic dysfunction.
Our SS-31 is synthesized in an ISO 9001:2015 certified and GMP-grade manufacturing environment. By utilizing precision liquid-phase synthesis and multi-stage HPLC purification, we achieve a chemical purity of ≥99%. This high standard ensures the peptide is free from truncated sequences and residual chemical catalysts, guaranteeing the structural fidelity required for high-resolution studies into ATP production and mitochondrial membrane potential.
Research Applications & Mechanisms
Cardiolipin Stabilization
Investigating the molecular interaction between SS-31 and cardiolipin to study the stabilization of mitochondrial cristae and the optimization of the electron transport chain.
Mitigation of Oxidative Stress
Researching the peptide’s ability to selectively reduce mitochondrial ROS without interfering with necessary cytosolic signaling ROS.
Neuroprotective Signaling
Studying the influence of mitochondrial repair on neuronal survival and synaptic plasticity in experimental models of neurodegenerative decline.
Microvascular & Renal Research
Exploring the role of SS-31 in preserving mitochondrial function within endothelial and renal epithelial cells under conditions of metabolic stress.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | SS-31 (Elamipretide) |
| Sequence | D-Arg-Dmt-Lys-Phe-NH2 |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | 639.8 Da |
| Concentration | Available in 10mg / 50mg vials |
| Solubility | Highly Soluble in Water (Aqueous) / Sterile Saline |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the SS-31 powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid reconstitution and protects the tetrapeptide from oxidative degradation during storage.
Batch Consistency
Every batch undergoes rigorous Mass Spectrometry (MS) to confirm sequence identity and HPLC to verify that purity levels exceed 99%, ensuring reproducible results across long-term research projects.
Reconstitution & Storage
Reconstitution Guide
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Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the SS-31 cake is at the base.
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Solvent: Reconstitute with Sterile Water or 0.9% Normal Saline.
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store at 2–8°C and utilize within 10-14 days.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the integrity of the SS-31 molecular structure.
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Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This SS-31 (Elamipretide) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
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National Center for Biotechnology Information (NCBI): Elamipretide Compound Summary (CID 9832204)
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ScienceDirect (Elsevier): Research on Mitochondrial-Targeted Peptides and Oxidative Stress
🔍 Deep Dive Research
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[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
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[Bioenergetics Study]: The Role of SS-31 in Cardiolipin Binding and Mitochondrial Recovery
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