MOTS-c (Human)
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a potent, naturally occurring 16-amino acid signaling peptide encoded by the mitochondrial genome. In the field of advanced metabolic research and geroscience, MOTS-c is highly distinguished for its role as a “mitochondrial hormone” that coordinates communications between mitochondria and the nucleus. Its primary mechanism involves the activation of the AMPK (AMP-activated protein kinase) pathway and the promotion of AICAR levels, which collectively enhance glucose uptake and fatty acid oxidation. It provides researchers with a robust experimental tool to investigate metabolic flexibility, insulin sensitivity, and cellular longevity signaling across various tissue models.
Our MOTS-c is synthesized in an ISO 9001:2015 certified and GMP-grade manufacturing environment. Utilizing state-of-the-art solid-phase synthesis and high-resolution multi-stage HPLC purification, we achieve an ultra-high chemical purity of ≥99%. This meticulous production standard ensures the peptide is free from truncated isomers and residual synthesis catalysts, guaranteeing the consistency required for high-stakes research into mitochondrial-nuclear communication and cellular energetics.
Research Applications & Mechanisms
AMPK Pathway & Glucose Metabolism
Investigating the peptide’s ability to activate AMPK signaling to study non-insulin-dependent glucose uptake in skeletal muscle models.
Mitochondrial-Nuclear Signaling
Researching how MOTS-c translocates to the nucleus under metabolic stress to regulate gene expression and cellular adaptation.
Lipid Oxidation & Thermogenesis
Studying the pathways through which MOTS-c influences fatty acid metabolism and its potential role in investigating metabolic dysfunction-associated syndromes.
Exercise Mimetic & Longevity Research
Exploring the role of mitochondrial-derived peptides in simulating the metabolic benefits of physical activity and their impact on age-related physiological decline.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | MOTS-c (Human) |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Ala-Leu-Ser-Lys-Leu-Leu |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | 2174.6 Da |
| Concentration | 10mg / 15mg / 20mg / 40mg per vial |
| Bulk Availability | Wholesale / Bulk Orders Supported |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Wholesale-Grade Manufacturing
We specialize in large-scale production (bulk wholesale) of MOTS-c, maintaining identical purity and stability standards for single vials and high-volume orders. This ensures that long-term, large-sample-size studies remain consistent across batches.
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the MOTS-c powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid reconstitution and protects the sensitive mitochondrial sequence from oxidative degradation.
Reconstitution & Storage
Reconstitution Guide
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Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the MOTS-c cake is at the base.
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Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store at 2–8°C and utilize within 10-14 days.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the integrity of the MOTS-c molecular structure.
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Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
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Wholesale Inquiries: For bulk pricing and custom synthesis, please contact our laboratory sales team.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This MOTS-c is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
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National Center for Biotechnology Information (NCBI): MOTS-c A promising mitochondrial-derived peptide for therapeutic exploitation.
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ScienceDirect (Elsevier):Mitochondrial-derived peptide MOTS-c targets SLC7A11 to preserve spermatogenesis by suppressing ferroptosis
🔍 Deep Dive Research
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[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
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[Metabolic Study]: The Mitochondrial Revolution: Exploring MOTS-c in Modern Bioenergetics Research
carolgutierrez –
Pretty satisfied.