IGF-1 LR3
IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a high-purity, synthetic 83-amino acid analog of human IGF-1. In the landscape of advanced molecular biology and tissue engineering, IGF-1 LR3 is distinguished by its significantly enhanced potency and extended biological half-life. By replacing Glutamic Acid with Arginine at the 3rd position and adding a 13-amino acid extension at the N-terminus, this “Long R3” version exhibits an extremely low affinity for IGF-Binding Proteins (IGFBPs). This crucial modification ensures that the peptide remains in its free, active state within experimental models, providing researchers with a robust tool to investigate prolonged cellular proliferation, DNA synthesis, and the molecular pathways of skeletal muscle hypertrophy and systemic regeneration.
Our IGF-1 LR3 is synthesized in an ISO 9001:2015 certified environment utilizing high-precision recombinant DNA technology or advanced Solid-Phase Synthesis. We achieve an ultra-high chemical purity of ≥99%, verified by HPLC and Mass Spectrometry (MS). This rigorous production standard ensures the peptide is free from truncated sequences and residual synthesis reagents, guaranteeing the consistency required for high-stakes research into metabolic signaling and protein synthesis upregulation.
Research Applications & Mechanisms
Cellular Proliferation & Differentiation
Investigating the potentiation of the PI3K/Akt pathway to study increased hyperplasia and the formation of new cellular structures in research models.
Myogenic Hypertrophy & Tissue Repair
Researching the role of IGF-1 LR3 in activating satellite cells to investigate accelerated skeletal muscle repair and dermal tissue regeneration.
Insulin Signaling & Glucose Transport
Studying the peptide’s influence on glucose uptake in experimental tissue, providing a model to research systemic metabolic efficiency and insulin-like effects.
Inhibiting Cellular Apoptosis
Exploring the anti-apoptotic properties of long-acting IGF-1 to study cellular longevity and protection against programmed cell death in degenerative models.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | IGF-1 LR3 (Long R3 IGF-1) |
| Sequence | 83 Amino Acid Analog of Human IGF-1 |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | 9111.6 Da |
| Concentration | Available in 100mcg / 1mg vials |
| Solubility | Soluble in Water / 10mM Acetic Acid / Bacteriostatic Water |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the IGF-1 LR3 powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the structural integrity of the complex 83-amino acid sequence during storage.
Enhanced Bioavailability Profile
The LR3 modification ensures maximal receptor binding affinity by bypassing the inhibitory effects of binding proteins, providing predictable and powerful results in all experimental designs.
Reconstitution & Storage
Reconstitution Guide
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Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the IGF-1 LR3 cake is at the base.
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Solvent: Reconstitute with 10mM Acetic Acid or Bacteriostatic Water (Note: IGF-1 LR3 is most stable at a slightly acidic pH).
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store at 2–8°C and utilize within 7-10 days for optimal results.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the IGF-1 LR3 peptide.
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Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This IGF-1 LR3 is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
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National Center for Biotechnology Information (NCBI): Compound Summary – IGF-1 LR3 (Long Arg3 IGF-1 analogue)
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PubMed – NIH: Research on IGF-1 LR3 and insulin-like growth factor signaling in growth and metabolism
🔍 Deep Dive Research
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[Technical Guide]: Optimizing Stability: Best Practices for IGF-1 LR3 Reconstitution
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[Tissue Study]: Beyond the Pulse: Exploring IGF-1 LR3 in Modern Hyperplasia Research
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