Snap-8 (Acetyl Octapeptide-3)
Snap-8, chemically known as Acetyl Octapeptide-3, is a potent synthetic peptide designed as an elongation of the popular hexapeptide Argireline. In the field of advanced biochemical and dermatological research, Snap-8 is a primary focus for its ability to modulate the SNARE (SNAP-Receptor) complex. By competing with natural proteins for a position in this complex, Snap-8 destabilizes the vesicle fusion process, thereby inhibiting the release of catecholamines—specifically acetylcholine—at the neuromuscular junction. This mechanism provides researchers with a high-precision tool to study the attenuation of muscle contractions and cellular signaling in aging and skin-rejuvenation models.
Our Snap-8 is synthesized in an ISO 9001:2015 certified and GMP-grade manufacturing environment. Utilizing state-of-the-art solid-phase synthesis and multi-stage HPLC purification, we achieve a chemical purity of ≥99%. This meticulous production standard ensures the peptide is free from truncated isomers and residual chemical reagents, guaranteeing the consistency required for sensitive in-vitro studies and comparative analysis against other neuropeptides.
Research Applications & Mechanisms
SNARE Complex Destabilization
Investigating the competitive inhibition mechanism of Snap-8 to study the controlled reduction of neurotransmitter exocytosis.
Neuro-Muscular Junction Signaling
Researching the peptide’s influence on acetylcholine release and its subsequent effect on muscle fiber tonicity in experimental models.
Comparative Peptide Efficiency
Studying the increased potency of octapeptides (8 amino acids) versus hexapeptides (6 amino acids) in modulating cellular fusion proteins.
Dermal Matrix Homeostasis
Exploring the role of Snap-8 in reducing mechanical stress on the extracellular matrix to observe its effects on structural integrity in aging tissue research.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | Snap-8 (Acetyl Octapeptide-3) |
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | 1075.2 Da |
| Concentration | Available in 10mg / 100mg vials |
| Solubility | Highly Soluble in Water (Aqueous) / Bacteriostatic Water |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the Snap-8 powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and prevents the octapeptide chain from environmental degradation.
High-Fidelity Sequence Verification
Every batch undergoes rigorous Mass Spectrometry (MS) to confirm the exact 8-amino acid sequence, ensuring maximum biological activity and reproducible data in research environments.
Reconstitution & Storage
Reconstitution Guide
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Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the Snap-8 cake is at the base.
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Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store at 2–8°C and utilize within 10-14 days.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to protect the Snap-8 molecular structure.
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Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This Snap-8 (Acetyl Octapeptide-3) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
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PubMed – NIH: Research on Acetyl Octapeptide-3 (SNAP-8) and wrinkle reduction / neurotransmitter inhibition peptides
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ScienceDirect (Elsevier): Peer-reviewed Research on SNARE Complex Modulation and Neuropeptides
🔍 Deep Dive Research
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[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
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[Neuro-signaling Study]: From Argireline to Snap-8: The Evolution of SNARE Complex Inhibitors










morenoesmeo –
Works for my needs.