Matrixyl (Palmitoyl Pentapeptide-4) – 10mg

Overview

Matrixyl, scientifically designated as Palmitoyl Pentapeptide-4 (formerly Pal-KTTKS), is one of the most rigorously studied signal peptides in the field of regenerative dermatology and molecular biology. Composed of five amino acids linked to a palmitic acid chain for enhanced lipophilicity, Matrixyl functions as a “matrikine”—a messenger peptide that mimics fragments of broken-down collagen. In laboratory research, Matrixyl is highly distinguished by its ability to stimulate the Extracellular Matrix (ECM), specifically targeting the upregulation of Collagen I, III, and IV, as well as fibronectin and glycosaminoglycans. It provides researchers with a precise experimental model to investigate the reversal of photo-aging, the stabilization of the dermal-epidermal junction (DEJ), and the molecular signaling of fibroblast activation.

Our Matrixyl is synthesized in an ISO 9001:2015 certified and GMP-grade manufacturing environment. Utilizing state-of-the-art solid-phase synthesis and high-resolution multi-stage HPLC purification, we achieve an ultra-high chemical purity of ≥99%. This meticulous production standard ensures the peptide is free from truncated sequences and residual fatty acid reagents, guaranteeing the consistency and structural fidelity required for high-stakes research into tissue repair and cellular rejuvenation.

Research Applications & Mechanisms

Collagen & Elastin Biosynthesis

Investigating the upregulation of structural proteins within the dermis to study the enhancement of skin elasticity and tensile strength.

Fibroblast Proliferation & Activation

Researching the signaling pathways through which Matrixyl triggers dormant fibroblasts to resume the production of essential matrix components.

Dermal-Epidermal Junction (DEJ) Integrity

Studying the peptide’s role in strengthening the basement membrane zone to investigate improved nutrient exchange and skin stability.

Glycosaminoglycan (GAG) Regulation

Exploring the influence of Palmitoyl Pentapeptide-4 on the production of hyaluronic acid and other moisture-retaining molecules in experimental skin models.

Technical Specifications

Key Features & Quality Assurance

Pharmaceutical-Grade Lyophilization

Our proprietary vacuum-sealing process ensures the Matrixyl powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the molecular stability of the pentapeptide sequence during storage.

Optimized Lipophilic Fidelity

The palmitoyl chain attachment is precisely verified through Mass Spectrometry (MS) to ensure optimal cellular penetration and receptor interaction in specialized in-vitro assays.

Reconstitution & Storage

Reconstitution Guide

• Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the Matrixyl cake is at the base.

• Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.

• Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.

Storage Protocols

• Long-term: Store at -20°C (Maintains potency for up to 24 months).

• Short-term: Stable at 2–8°C for up to 3 months.

• Post-Reconstitution: Store at 2–8°C and utilize within 14-21 days for optimal results.

Shipping & Documentation

• Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the Matrixyl peptide.

• Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.

• Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).

⚠️ Research Disclaimer

Product-Specific Safety Notice: This Matrixyl (Palmitoyl Pentapeptide-4) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.

Scientific Resources & References

• National Center for Biotechnology Information (NCBI): Palmitoyl Pentapeptide-4 Compound Summary

• Matrixyl, and Rhamnose stimulates the gene and protein expression of different collagens in fibroblasts: results from an in vitro study 

🔍 Deep Dive Research

• [Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency

• [ECM Study]: The Matrikine Revolution: Exploring Matrixyl in Modern Regenerative Research