Gonadorelin Acetate（GnRH）
Gonadorelin Acetate is a high-purity synthetic decapeptide, identical in structure and function to the endogenous Gonadotropin-Releasing Hormone (GnRH). In the landscape of advanced neuroendocrinology, Gonadorelin is recognized as the master regulator of the reproductive axis. It functions by binding to specific receptors on the gonadotropic cells of the anterior pituitary gland, thereby stimulating the synthesis and pulsatile release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). This provides researchers with a direct experimental model to investigate the initiation of steroidogenesis, the dynamics of the Hypothalamic-Pituitary-Gonadal (HPG) axis, and the molecular signaling involved in germ cell maturation and hormonal feedback loops.
Our Gonadorelin Acetate is synthesized in an ISO 9001:2015 certified environment utilizing high-precision Solid-Phase Peptide Synthesis (SPPS). We achieve an ultra-high chemical purity of ≥99% (Acetate Salt form), verified by HPLC and Mass Spectrometry (MS). This rigorous production standard ensures the peptide is free from truncated sequences and residual chemical catalysts, guaranteeing the consistency and biological potency required for high-fidelity endocrine assays.
Research Applications & Mechanisms
Pituitary Response & Gonadotropin Release
Investigating the direct stimulatory effects of GnRH agonism on the secretion patterns of LH and FSH in experimental models.
HPG Axis Mapping & Feedback Regulation
Researching the systemic interaction between the hypothalamus, pituitary, and gonads to study the mitigation of secondary hypogonadism in research designs.
Reproductive Physiology & Germ Cell Development
Studying the mechanisms through which Gonadorelin influences follicular maturation in females and spermatogenesis in male research models.
Neuroendocrine Signaling & Pulse Modulation
Exploring the impact of different administration frequencies (pulsatile vs. continuous) on the downregulation or sensitization of GnRH receptors.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | Gonadorelin Acetate |
| Sequence | Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | 1182.3 Da |
| Concentration | Available in 2mg / 5mg vials |
| Solubility | Highly Soluble in Water (Aqueous) / Bacteriostatic Water |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the Gonadorelin Acetate powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and protects the decapeptide from oxidative degradation during storage.
High-Fidelity Sequence Integrity
Every batch undergoes strict Mass Spectrometry (MS) to confirm the exact amino acid sequence, ensuring maximal receptor binding affinity and reproducible results in complex hormonal signaling assays.
Reconstitution & Storage
Reconstitution Guide
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Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the Gonadorelin cake is at the base.
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Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store at 2–8°C and utilize within 10-14 days for optimal results.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the Gonadorelin Acetate peptide.
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Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This Gonadorelin Acetate is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
- Detailed chemical, structural, and endocrine peptide data for Gonadorelin Acetate (GnRH, Gonadotropin-Releasing Hormone) can be accessed via PubChem.
- Curated biological function, receptor interaction, and hormone signaling pathway information for Gonadorelin is available through KEGG.
🔍 Deep Dive Research
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[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
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[Endocrine Study]: The Master Regulator: Exploring Gonadorelin in Modern Reproductive Research
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