Overview
CJC-1295 with DAC (Drug Affinity Complex) is a high-purity synthetic tetra-substituted peptide analog of the endogenous Growth Hormone-Releasing Hormone (GHRH). In the landscape of advanced endocrinology, this peptide is distinguished by its innovative modification: the addition of a DAC moiety at the C-terminus. This allows the peptide to bind covalently to circulating albumin after administration, effectively shielding it from rapid enzymatic degradation and renal clearance. While standard GHRH analogs have a half-life of less than 30 minutes, CJC-1295 with DAC provides a significantly extended biological half-life of up to 7–8 days. It serves as a robust experimental model to investigate sustained pulsatile GH secretion, systemic IGF-1 upregulation, and long-term metabolic homeostasis.
Our CJC-1295 with DAC is synthesized in an ISO 9001:2015 certified environment utilizing precision Solid-Phase Peptide Synthesis (SPPS). We achieve an ultra-high chemical purity of ≥99%, verified by HPLC and Mass Spectrometry (MS). This rigorous production standard ensures the peptide is free from truncated sequences and residual chemical catalysts, guaranteeing the consistency and structural fidelity required for high-stakes studies into protein synthesis and tissue regeneration.
Research Applications & Mechanisms
Sustained GH & IGF-1 Upregulation
Investigating the continuous stimulation of the pituitary gland to study the long-term elevation of serum IGF-1 levels in research models.
Metabolic Rate & Lipid Oxidation
Researching the mechanisms through which extended GHRH signaling influences fat metabolism and systemic energy expenditure.
Tissue Repair & Cellular Hypertrophy
Studying the role of CJC-1295 with DAC in accelerating the repair of skeletal muscle and connective tissues through enhanced protein nitrogen retention.
Pituitary Sensitivity & Feedback Loops
Exploring the impact of prolonged GHRH receptor activation on somatotroph responsiveness and the systemic somatostatin feedback mechanism.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | CJC-1295 with DAC |
| Sequence | Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(DAC)-NH2 |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | 3367.9 Da (Base Peptide) |
| Concentration | Available in 2mg / 5mg vials |
| Solubility | Highly Soluble in Water (Aqueous) / Bacteriostatic Water |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the CJC-1295 with DAC powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains molecular stability during long-term storage.
DAC Integration Precision
Every batch is verified through Mass Spectrometry (MS) to confirm the successful conjugation of the DAC complex, ensuring the characteristic extended half-life and reproducible research data.
Reconstitution & Storage
Reconstitution Guide
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Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the CJC-1295 cake is at the base.
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Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store at 2–8°C and utilize within 10-14 days for optimal results.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the CJC-1295 with DAC peptide.
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Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This CJC-1295 with DAC is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
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National Center for Biotechnology Information (NCBI): GHRH Analogs and Half-Life Extension Research
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ScienceDirect (Elsevier): Peer-reviewed Research on CJC-1295 and Metabolic Signaling
🔍 Deep Dive Research
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[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
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[Endocrine Study]: The DAC Advantage: Exploring Extended GHRH Signaling in Research
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Straightforward process.