Epithalon (Epitalon)
Epithalon (also known as Epitalon or ET) is a high-purity synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly. Derived from the naturally occurring polypeptide Epithalamin produced in the pineal gland, Epithalon is a cornerstone of modern gerontology and longevity research. Its primary mechanism involves the upregulation of the enzyme Telomerase, which facilitates the elongation of telomeres—the protective caps at the ends of chromosomes. In advanced cellular research, Epithalon is utilized to investigate the reversal of the “Hayflick Limit,” cellular rejuvenation, and the restoration of circadian rhythm stability. By modulating the secretion of endogenous melatonin and normalizing neuroendocrine function, Epithalon provides researchers with a robust experimental model for studying systemic aging delay and genomic stability.
Our Epithalon is synthesized in an ISO 9001:2015 certified environment utilizing high-precision Solid-Phase Peptide Synthesis (SPPS). We achieve an ultra-high chemical purity of ≥99%, verified by HPLC and Mass Spectrometry (MS). This rigorous production standard ensures the peptide is free from truncated sequences and residual synthesis reagents, guaranteeing the consistency and biological fidelity required for long-term aging studies and epigenetic research.
Research Applications & Mechanisms
Telomerase Activation & Chromosome Integrity
Investigating the upregulation of the hTERT gene to study telomere elongation and the prevention of cellular senescence in specialized cell lines.
Circadian Rhythm & Melatonin Regulation
Researching the peptide’s influence on the pineal gland to investigate the restoration of sleep-wake cycles and systemic hormonal equilibrium in aging models.
DNA Repair & Antioxidant Defense
Studying the mechanisms through which Epithalon enhances the activity of antioxidant enzymes (such as SOD and Glutathione Peroxidase) to protect DNA from oxidative damage.
Neuroendocrine & Immune System Support
Exploring the influence of Epithalon on thymus function and T-cell proliferation to research the mitigation of age-related immune decline (immunosenescence).
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | Epithalon (Epitalon) |
| Sequence | Ala-Glu-Asp-Gly |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | 390.35 g/mol |
| Concentrations | Available in 10mg / 50mg vials |
| Solubility | Highly Soluble in Water (Aqueous) / Bacteriostatic Water |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the Epithalon powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the molecular stability of the tetrapeptide during long-term storage.
High-Fidelity Sequence Integrity
Every batch undergoes strict Mass Spectrometry (MS) to confirm the exact amino acid sequence, ensuring maximal target binding and reproducible results in longitudinal aging research.
Reconstitution & Storage
Reconstitution Guide
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Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the Epithalon cake is at the base.
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Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store at 2–8°C and utilize within 14-20 days for optimal results.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the Epithalon peptide.
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Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This Epithalon (ET) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
- Comprehensive chemical, structural, and biological data for Epithalon (Epitalon) can be accessed via PubChem
- Regulatory identifiers, synonyms, and curated biomedical information for Epithalon are available through DrugBank.
🔍 Deep Dive Research
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[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
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[Longevity Study]: The Telomere Edge: Exploring Epithalon in Modern Gerontology
gladneykristin –
Product seems consistent.