Overview
Liraglutide is a high-purity synthetic analog of the naturally occurring human incretin hormone, glucagon-like peptide-1 (GLP-1). In the landscape of advanced metabolic and endocrinology research, Liraglutide is highly distinguished by its extended half-life, achieved through a unique C-16 fatty acid (palmitoyl) chain attachment that promotes albumin binding and resistance to dipeptidyl peptidase-4 (DPP-4) degradation. As a potent GLP-1 Receptor Agonist, it provides researchers with a sophisticated experimental model to study glucose-dependent insulin secretion, the suppression of inappropriate glucagon release, and the molecular mechanisms of delayed gastric emptying. Its role in modulating hypothalamic appetite centers makes it an essential tool for investigating long-term energy balance and adipose tissue regulation.
Our Liraglutide is synthesized in an ISO 9001:2015 certified and GMP-grade manufacturing environment. Utilizing state-of-the-art solid-phase synthesis and high-resolution multi-stage HPLC purification, we achieve an ultra-high chemical purity of ≥99%. This meticulous production standard ensures the peptide is free from truncated isomers and residual synthesis reagents, guaranteeing the consistency and structural fidelity required for sensitive longitudinal studies into metabolic dysfunction and cellular signaling.
Research Applications & Mechanisms
Glucoregulatory Signaling
Investigating the activation of the GLP-1 receptor to study insulinotropic pathways and the preservation of pancreatic $\beta$-cell function in experimental models.
Central Appetite Regulation
Researching the peptide’s influence on the pro-opiomelanocortin (POMC) neurons in the hypothalamus to study satiety signaling and caloric intake reduction.
Gastric Motility & Nutrient Absorption
Studying the mechanisms through which Liraglutide modulates gastrointestinal transit time to investigate postprandial glucose fluctuations.
Cardiovascular & Neuroprotective Research
Exploring the pleiotropic effects of GLP-1 agonism on endothelial function and its potential role in mitigating neuroinflammatory markers in neurodegenerative models.
H2: Technical Specifications
| Parameter | Laboratory Standard |
| Compound | Liraglutide |
| Sequence | [Arg34, Lys26]-(N-$\epsilon$-(γ-Glu(N-$\alpha$-palmitoyl)))-GLP-1(7-37) |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | 3751.2 Da |
| Concentration | Available in 5mg / 10mg / 30mg vials |
| Solubility | Highly Soluble in Water (Aqueous) / Bacteriostatic Water |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the Liraglutide powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the molecular stability of the palmitoylated sequence during long-term storage.
Structural Fidelity & Stability
Every batch undergoes strict Mass Spectrometry (MS) to confirm the exact acylation site and sequence integrity, ensuring maximal receptor binding affinity and reproducible results in laboratory assays.
Reconstitution & Storage
Reconstitution Guide
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Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the Liraglutide cake is at the base.
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Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store at 2–8°C and utilize within 14-21 days for optimal results.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the Liraglutide peptide.
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Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This Liraglutide is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
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National Center for Biotechnology Information (NCBI): Liraglutide Compound Summary (CID 16135471)
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ScienceDirect (Elsevier): Glucagon-like peptide-1 analog, liraglutide, alters blood-testis barrier permeability in juvenile healthy rats.
🔍 Deep Dive Research
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[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
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[Metabolic Study]: Beyond Glycemic Control: The Role of Liraglutide in Modern Obesity Research
thizzbit –
Packaging was neat.