Thymosin alpha 1
Thymosin Alpha 1 (Tα1) is a chemically synthesized, 28-amino acid polypeptide that precisely mimics the naturally occurring hormone secreted by the thymus gland. In the field of advanced biochemical research, Tα1 is a critical focus for its multifaceted role as a potent immunomodulator. It is primarily utilized in laboratory settings to investigate the complex activation and differentiation pathways of T-lymphocytes. By interacting with various Toll-like receptors, Thymosin Alpha 1 provides researchers with a robust experimental instrument to study the host’s innate and adaptive defense mechanisms against viral replication and cellular senescence.
Our Thymosin Alpha 1 is produced within an ISO 9001:2015 certified and GMP-grade manufacturing environment. We employ advanced solid-phase peptide synthesis (SPPS) and rigorous multi-step HPLC purification to achieve an ultra-high chemical purity of ≥99%. This extreme precision ensures that your research into cytokine regulation and immune signaling remains untainted by synthetic by-products or bio-contaminants, allowing for high-fidelity, reproducible data collection in sensitive in-vitro and in-vivo models.
Research Applications & Mechanisms
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T-Lymphocyte Maturation: Investigating the molecular triggers through which Tα1 promotes the maturation of CD3+, CD4+, and CD8+ cells.
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Antiviral Signaling Research: Studying the inhibitory effects of the Tα1 sequence on viral entry and intracellular replication within host cells.
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Cytokine Homeostasis: Researching the peptide’s ability to balance pro-inflammatory and anti-inflammatory cytokines, specifically involving IL-2 and IFN-γ cascades.
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Immunosenescence Models: Exploring the role of thymic peptides in restoring immune function within aging biological models.
Technical Specifications
| Parameter | Laboratory Standard |
| Manufacturing Standard | ISO 9001:2015 Certified Facility |
| Production Quality | GMP-Level Compliance |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | 3108.3 Da |
| Sequence Verification | Verified via Mass Spectrometry (MS) |
| Solubility | Highly Soluble in Water / Bacteriostatic Water |
Key Features & Quality Assurance
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Pharmaceutical-Grade Lyophilization: Our specialized freeze-drying technology ensures the surface of the Thymosin Alpha 1 powder is perfectly smooth, flat, and delicate. This uniform cake structure prevents moisture absorption and maintains the long-term structural integrity of the peptide chain.
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Unrivaled Batch Consistency: Rigorous internal audits ensure that every vial of Tα1 meets the exact same molecular profile, ensuring the reliability of longitudinal research data.
Reconstitution Guide (Important)
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Preparation: Allow the vial to reach room temperature. Centrifuge the vial for 30-60 seconds to ensure the Tα1 cake is positioned at the bottom.
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Solvent: Reconstitute with Sterile Water or 0.9% Normal Saline.
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl the vial softly until the solution is completely clear and transparent.
Storage & Handling
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store reconstituted Tα1 solution at 2–8°C and utilize within 10-14 days for optimal results.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to protect the Thymosin Alpha 1 molecular structure.
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Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This Thymosin Alpha 1 (Tα1) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals using appropriate safety protocols.
Scientific Resources & References
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National Center for Biotechnology Information (NCBI): Compound Summary – Thymosin Alpha-1 (CID: 16133750)
- Chemical Abstracts Service (CAS): Registry Record – Thymosin Alpha-1 (CAS RN: 62304-98-7)
- PubMed – NIH: Research literature on Thymosin Alpha-1 immune modulation and therapeutic applications
🔍 Deep Dive Research
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[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
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[Immune Study]: The Role of Thymosin Alpha 1 in Modern Viral Defense Models
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