Semax
Semax is a high-potency synthetic heptapeptide and a stabilized analog of the ACTH (4-10) fragment (Met-Glu-His-Phe-Pro-Gly-Pro). In the landscape of neuroscience and regenerative research, Semax is primarily recognized for its profound neurotrophic and neuroprotective properties. Unlike traditional stimulants, Semax operates by modulating the expression of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) within the hippocampus and cerebral cortex. It provides researchers with a robust experimental tool to investigate neuronal survival, synaptic plasticity, and the acceleration of recovery in models of ischemic brain injury and neurodegenerative decline.
Our Semax is synthesized in an ISO 9001:2015 certified and GMP-grade manufacturing environment. By utilizing advanced Solid-Phase Peptide Synthesis (SPPS) and rigorous multi-stage HPLC purification, we achieve an ultra-high chemical purity of ≥99%. This meticulous production standard ensures the peptide is free from truncated fragments and residual chemical reagents, guaranteeing the consistency required for high-resolution studies into neurotransmitter balance and cerebral blood flow regulation.
Research Applications & Mechanisms
Neurotrophic Factor Modulation
Investigating the upregulation of BDNF and NGF mRNA expression to study the mechanisms of neuronal repair and dendritic branching.
Ischemic Recovery & Neuroprotection
Researching the peptide’s influence on reducing glutamate excitotoxicity and oxidative stress in experimental models of cerebral ischemia.
Cognitive Enhancement Signaling
Studying the influence of Semax on the cholinergic and serotonergic systems to observe its effects on memory consolidation and learning focus.
Anti-Inflammatory Action in the CNS
Exploring the role of the ACTH 4-10 sequence in modulating the cytokine profile within the central nervous system during systemic inflammatory stress.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | Semax (ACTH 4-10 Fragment Analog) |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | 812.9 Da |
| Concentration | Available in 5mg / 10mg vials |
| Solubility | Highly Soluble in Water (Aqueous) / Bacteriostatic Water |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the Semax powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid reconstitution and protects the heptapeptide from molecular degradation during long-term storage.
Enhanced Molecular Stability
By incorporating the Pro-Gly-Pro sequence at the C-terminus, our synthetic Semax is engineered for increased resistance to enzymatic degradation, allowing for sustained activity in research media.
Reconstitution & Storage
Reconstitution Guide
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Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the Semax cake is at the base.
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Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store at 2–8°C and utilize within 10-14 days.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the Semax peptide.
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Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This Semax is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
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PubMed – NIH: Research on Semax and ACTH(4-10) peptide analogs in neuroprotection and cognitive function
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ScienceDirect (Elsevier): Peer-reviewed Research on BDNF Expression and Synthetic Heptapeptides
🔍 Deep Dive Research
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[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
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[Nootropic Study]: The Mechanism of BDNF Upregulation: Analyzing Semax in Cognitive Research
damianm –
Clean and simple packaging.