Overview
Melanotan II (MT2) is a high-purity, synthetic cyclic analog of the endogenous mammalian peptide $\alpha$-melanocyte-stimulating hormone ($\alpha$-MSH). In the landscape of advanced dermatological and neuro-endocrine research, MT2 is distinguished by its non-selective agonism across the Melanocortin receptors (MC1R, MC3R, MC4R, and MC5R). Unlike linear peptides, MT2 features a specialized cyclic structure that significantly enhances its resistance to enzymatic degradation and increases its binding affinity. It provides researchers with a robust experimental tool to investigate systemic melanogenesis, the protective mechanisms against UV-induced DNA damage, and the complex central nervous system pathways regulating appetite and sexual function signaling.
Our Melanotan II is synthesized in an ISO 9001:2015 certified and GMP-grade manufacturing environment. Utilizing state-of-the-art solid-phase synthesis and high-resolution multi-stage HPLC purification, we achieve an ultra-high chemical purity of ≥99%. This meticulous production standard ensures the peptide is free from truncated isomers and residual synthesis catalysts, guaranteeing the consistency and structural fidelity required for high-fidelity research into pigmentation homeostasis and metabolic signaling.
Research Applications & Mechanisms
Melanogenesis & Photoprotection Research
Investigating the activation of MC1R on melanocytes to study the non-UV dependent synthesis of eumelanin and its role in experimental photo-protection models.
Central Melanocortin Signaling & Satiety
Researching the activation of MC3R and MC4R pathways to observe the peptide’s influence on energy homeostasis, lipid metabolism, and appetite suppression.
Neuro-Vascular & Erectile Signaling
Studying the mechanisms through which MT2 interacts with hypothalamic receptors to influence autonomic sexual response pathways in experimental designs.
Cellular DNA Repair & Integrity
Exploring the potential of melanocortin activation to mitigate oxidative stress and enhance the genomic stability of skin cells under environmental stressors.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | Melanotan II (MT2) |
| Structure | Cyclic Heptapeptide Analog |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | 1024.2 Da |
| Concentration | 10mg per vial |
| Solubility | Highly Soluble in Water (Aqueous) / Bacteriostatic Water |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the Melanotan II powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the molecular stability of the cyclic structure during long-term storage.
Structural Fidelity & Purity
Every batch undergoes strict Mass Spectrometry (MS) to confirm the exact cyclic sequence, ensuring maximal receptor binding affinity and reproducible results in laboratory assays.
Reconstitution & Storage
Reconstitution Guide
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Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the MT2 cake is at the base.
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Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store at 2–8°C and utilize within 14-21 days for optimal results.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the Melanotan II peptide.
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Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This Melanotan II (MT2) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
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National Center for Biotechnology Information (NCBI): Melanotan II Compound Summary (CID 92432)
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ScienceDirect (Elsevier): Melanotan II nasal spray: a possible risk factor for oral mucosal malignant melanoma?
🔍 Deep Dive Research
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[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
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[Photobiology Study]: Beyond Pigmentation: Exploring the Role of MT2 in Modern Melanocortin Research
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