Dulaglutide
Dulaglutide is a high-purity, synthetic fusion protein that functions as a potent Glucagon-Like Peptide-1 (GLP-1) receptor agonist. In the field of advanced metabolic research, Dulaglutide is distinguished by its innovative molecular architecture: it consists of two identical chains of a GLP-1 analog, modified to resist DPP-4 degradation, each covalently linked to a modified human immunoglobulin G4 (IgG4) Fc fragment. This fusion significantly increases its molecular size and reduces renal clearance, resulting in a prolonged biological half-life. It provides researchers with a robust experimental model to investigate glucose-dependent insulin secretion, the inhibition of inappropriate glucagon release, and the molecular mechanisms of delayed gastric emptying and appetite suppression.
Our Dulaglutide is produced in an ISO 9001:2015 certified environment utilizing advanced recombinant DNA technology in mammalian cell lines to ensure proper protein folding and glycosylation. We achieve an ultra-high chemical purity of ≥99%, verified by HPLC and Mass Spectrometry (MS). This rigorous production standard ensures the peptide is free from bacterial endotoxins and truncated variants, guaranteeing the high-fidelity data necessary for longitudinal studies into metabolic homeostasis and weight regulation pathways.
Research Applications & Mechanisms
Glycemic Control & Insulin Signaling
Investigating the potentiation of glucose-dependent insulin secretion from pancreatic beta-cells in research models of metabolic dysfunction.
Satiety Mechanisms & Gastric Emptying
Researching the influence of GLP-1R activation on central nervous system satiety centers and its role in investigating delayed gastrointestinal motility.
Adipose Tissue & Weight Regulation
Studying the mechanisms through which long-acting GLP-1 analogs promote weight loss and influence lipid metabolism in experimental obesity studies.
Cardioprotective & Endothelial Research
Exploring the potential non-glycemic effects of Dulaglutide on cardiovascular stability and vascular endothelial health in systemic research designs.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | Dulaglutide |
| Structure | GLP-1-IgG4-Fc Fusion Protein |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | ~59.7 kDa |
| Concentrations | Available in 5mg / 10mg vials |
| Solubility | Highly Soluble in Water (Aqueous) / Sterile Saline |
| Batch Control | HPLC, MS & Endotoxin Analysis Verified |
Key Features & Quality Assurance
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the Dulaglutide powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure protects the large fusion protein during storage and ensures rapid, clear reconstitution.
Enhanced Half-Life Stability
The IgG4-Fc fusion design ensures that the peptide remains active in experimental models for extended periods, allowing for research into long-term metabolic adaptations without frequent dosing.
Reconstitution & Storage
Reconstitution Guide
-
Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the Dulaglutide cake is at the base.
-
Solvent: Reconstitute with Sterile Water or 0.9% Normal Saline.
-
Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl very gently until the solution is clear. Large fusion proteins are sensitive to mechanical agitation.
Storage Protocols
-
Long-term: Store at -20°C (Maintains potency for up to 24 months).
-
Short-term: Stable at 2–8°C for up to 3 months.
-
Post-Reconstitution: Store at 2–8°C and utilize within 14 days for optimal results.
Shipping & Documentation
-
Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the Dulaglutide protein.
-
Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
-
Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This Dulaglutide is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
- Comprehensive chemical, pharmacological, and structural data for Dulaglutide can be accessed via PubChem .
- Regulatory and clinical labeling information for Dulaglutide, including approved indications and pharmacological classification, is available through DailyMed
🔍 Deep Dive Research
-
[Technical Guide]: Handling Large Fusion Proteins: Best Practices for Dulaglutide Stability
-
[Metabolic Study]: The Extended Curve: Exploring Dulaglutide in Modern Obesity Research
aroadelarosamesa –
Communication was clear.