Sermorelin Acetate
Sermorelin Acetate, scientifically identified as GHRH (1-29) amide, is a synthetic polypeptide representing the shortest fully functional fragment of the endogenous human Growth Hormone-Releasing Hormone. In the landscape of endocrinology and metabolic research, Sermorelin serves as a primary secretagogue that selectively binds to the growth hormone-releasing hormone receptors (GHRHR) in the anterior pituitary gland. Unlike exogenous growth hormone, Sermorelin stimulates the natural, pulsatile release of GH, providing researchers with a more physiological model to study the somatotropic axis, negative feedback loops involving somatostatin, and the systemic regulation of IGF-1.
Our Sermorelin Acetate is synthesized in an ISO 9001:2015 certified and GMP-grade manufacturing environment. By utilizing precision Solid-Phase Peptide Synthesis (SPPS) and multi-step HPLC purification, we achieve an ultra-high chemical purity of ≥99%. This meticulous production standard ensures the absence of truncated sequences and residual reagents, providing the high-fidelity results necessary for accurate receptor-binding assays and longitudinal endocrine signaling studies.
Research Applications & Mechanisms
Pituitary Somatotroph Stimulation
Investigating the molecular pathways through which Sermorelin triggers the synthesis and secretion of endogenous growth hormone in pituitary cell cultures.
Somatotropic Axis Homeostasis
Researching the feedback mechanisms between IGF-1, Somatostatin, and GHRH analogs to study the regulation of metabolic rate and cellular growth.
Sleep & Circadian Rhythm Research
Studying the correlation between GHRH signaling and the regulation of slow-wave sleep (SWS) in experimental neurological models.
Gerontological Signaling
Exploring the role of GHRH fragments in mitigating age-related decline of growth hormone pulsatility and its impact on muscle and bone density markers.
H2: Technical Specifications
| Parameter | Laboratory Standard |
| Compound | Sermorelin Acetate (GHRH 1-29) |
| Sequence | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2 |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | 3357.9 Da |
| Concentration | Available in 2mg / 5mg / 10mg vials |
| Solubility | Highly Soluble in Water (Aqueous) / Bacteriostatic Water |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the Sermorelin Acetate powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and prevents the 29-amino acid chain from environmental degradation.
High-Fidelity Sequence Integrity
Every batch undergoes strict Mass Spectrometry (MS) to confirm the exact amino acid sequence, ensuring that the critical N-terminal domain required for receptor activation is fully preserved.
Reconstitution & Storage
Reconstitution Guide
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Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the Sermorelin cake is at the base.
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Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store at 2–8°C and utilize within 7-10 days for optimal results.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the integrity of the Sermorelin molecular structure.
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Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This Sermorelin Acetate is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
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PubMed – NIH: Clinical and endocrine research on Sermorelin (GHRH 1-29) and growth hormone secretion
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ScienceDirect (Elsevier): Research on GHRH Fragments and Growth Hormone Secretagogues
🔍 Deep Dive Research
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[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
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[Endocrine Study]: Understanding Pulsatile GH Release: The Role of GHRH 1-29 in Research
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