P21 (P021)
P21, also known as P021, is a high-potency synthetic derivative of the C-terminal fragment of the naturally occurring human Ciliary Neurotrophic Factor (CNTF). In the realm of advanced neuroscience and regenerative biology research, P21 is recognized as a superior neurotrophic mimetic that bypasses the limitations of its parent molecule, such as short half-life and poor blood-brain barrier permeability. Its primary mechanism involves modulating the BDNF (Brain-Derived Neurotrophic Factor) and GDNF (Glial Cell-Derived Neurotrophic Factor) signaling pathways. This provides researchers with a robust experimental tool to investigate the enhancement of hippocampal neurogenesis, the stabilization of synaptic plasticity, and the mitigation of cognitive decline in aging and neurodegenerative research models.
Our P21 is synthesized in an ISO 9001:2015 certified and GMP-grade manufacturing environment. By utilizing precision solid-phase synthesis and high-resolution multi-stage HPLC purification, we achieve an ultra-high chemical purity of ≥99%. This meticulous production standard ensures the peptide is free from truncated sequences and residual chemical reagents, guaranteeing the consistency required for sensitive long-term studies into neuronal maturation and memory consolidation.
Research Applications & Mechanisms
Hippocampal Neurogenesis & Maturation
Investigating the peptide’s ability to promote the proliferation and differentiation of neural stem cells into functional neurons within the dentate gyrus.
Synaptic Plasticity & LTP
Researching the influence of P21 on Long-Term Potentiation (LTP) and the density of dendritic spines in experimental cortical models.
BDNF/TrkB Pathway Modulation
Studying the mechanisms through which P21 mimics the beneficial effects of neurotrophic factors to study cellular survival under environmental stress.
Neurodegenerative Modeling
Exploring the potential of P21 to restore cognitive functions and reduce amyloid-beta or tau-related pathologies in early-stage neurodegeneration research.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | P21 (P021) |
| Origin | CNTF-Derived (C-terminal Fragment) |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | 563.6 Da |
| Concentration | 5mg per vial |
| Solubility | Highly Soluble in Water (Aqueous) / Bacteriostatic Water |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the P21 powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and protects the small-molecule peptide from oxidative degradation during storage.
High Bioavailability Design
As a miniaturized CNTF mimetic, our synthetic P21 is optimized for enhanced stability in research media, allowing for consistent observations in both in-vitro and systemic experimental designs.
Reconstitution & Storage
Reconstitution Guide
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Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the P21 cake is at the base.
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Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store at 2–8°C and utilize within 10-14 days.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the P21 peptide.
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Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This P21 (P021) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
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National Center for Biotechnology Information (NCBI): The role of p21 in cellular senescence and aging-related diseases.
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ScienceDirect (Elsevier): A potential role of cyclin-dependent kinase inhibitor 1 (p21/WAF1) in the pathogenesis of endometriosis: Directions for future research
🔍 Deep Dive Research
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[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
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[Cognitive Study]: The Future of Neurogenesis: Exploring the P21 Mechanism in Modern Brain Research
Charliejordan –
Quality seems consistent.