PEG MGF (Pegylated Mechano Growth Factor)
PEG MGF, or Pegylated Mechano Growth Factor, is a high-performance synthetic analog of the IGF-1 splice variant (IGF-1Ec). While native MGF is locally produced in response to mechanical stress or tissue injury, its extremely short half-life limits its experimental utility. By attaching a polyethylene glycol (PEG) molecule to the MGF peptide chain—a process known as Pegylation—the compound’s stability and systemic half-life are significantly extended. In the field of regenerative medicine and sports science research, PEG MGF is a primary tool for investigating the activation of muscle satellite cells, the acceleration of myoblast proliferation, and the molecular mechanisms of hypertrophy and skeletal muscle recovery.
Our PEG MGF is synthesized in an ISO 9001:2015 certified and GMP-grade manufacturing environment. Utilizing state-of-the-art solid-phase synthesis and high-resolution multi-stage HPLC purification, we achieve an ultra-high chemical purity of ≥99%. This meticulous production standard ensures the peptide is free from truncated isomers and residual synthesis catalysts, providing the consistent and reliable bioactivity required for sensitive cellular signaling studies.
Research Applications & Mechanisms
Satellite Cell Activation & Myogenesis
Investigating the peptide’s ability to trigger the recruitment and proliferation of dormant satellite cells for muscle tissue repair research.
Extended Half-Life & Systemic Stability
Studying the pharmacokinetics of the pegylated structure versus native MGF to observe sustained receptor activation in systemic research models.
Hypertrophic Signaling Pathways
Researching the upregulation of protein synthesis markers and the inhibition of myostatin signaling in experimental musculoskeletal studies.
Cardiovascular & Soft Tissue Recovery
Exploring the potential of PEG MGF in promoting cellular survival and repair in heart tissue and connective tissue (tendon/ligament) injury models.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | PEG MGF (Pegylated Mechano Growth Factor) |
| Base Peptide | IGF-1Ec (MGF) |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | ~2867.4 Da (plus PEG mass) |
| Concentration | 2mg per vial |
| Solubility | Highly Soluble in Water (Aqueous) / Bacteriostatic Water |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Advanced Pegylation Technology
Our proprietary pegylation process ensures the PEG molecule is precisely attached, preventing the peptide from rapid enzymatic degradation and allowing for a significantly longer observation window in research media.
Pharmaceutical-Grade Lyophilization
The PEG MGF powder surface is processed to be perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid reconstitution and maintains structural integrity during long-term storage.
Reconstitution & Storage
Reconstitution Guide
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Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the PEG MGF cake is at the base.
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Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store at 2–8°C and utilize within 10-14 days.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the integrity of the PEG MGF molecular structure.
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Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This PEG MGF is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
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National Center for Biotechnology Information (NCBI): Compound Summary – PEGylated Mechano Growth Factor (PEG-MGF / IGF-1 Ec variant)
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PubMed – NIH: Research on Mechano Growth Factor (MGF / IGF-1 Ec variant) in muscle regeneration and repair
🔍 Deep Dive Research
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[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
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[Regeneration Study]: The Role of PEG MGF in Satellite Cell Activation and Modern Hypertrophy Research
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