LL-37 Antimicrobial Peptide Lyophilized Powder - High Purity Immune System Research
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99% Purity LL-37 Powder - Lab-Tested Quality for Advanced Microbiology and Biohacking Research
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LL-37 (Cathelicidin) – Antimicrobial peptide 5mg

Rated 5.00 out of 5 based on 1 customer rating
(1 customer review)

$115.00

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PRODUCT SPECIFICATIONS

  • Compound: LL-37 (Human Cathelicidin Antimicrobial Peptide)
  • Purity: >= 99% (HPLC & MS Verified)
  • Form: White Lyophilized Fine Powder
  • Solubility: Soluble in Water or Sterile Saline (Aqueous)
  • CAS: 154947-66-7 | MW: 4493.3 g/mol
  • Storage: 2-8°C (Short-term) | -20°C (Long-term)
  • Shipping: Discrete packaging with a guaranteed reshipment policy.
⚠️ For Research Use Only. Not for human or veterinary applications.
SKU: P-LL37 Category: Tags: , ,
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Overview

LL-37 is the only member of the Cathelicidin family of antimicrobial peptides found in humans. Composed of 37 amino acids, this amphipathic alpha-helical peptide is released from the C-terminus of the hCAP18 protein by proteinase 3. In the field of advanced immunology and microbiology research, LL-37 is highly distinguished for its pleiotropic roles—extending far beyond simple pathogen neutralization. It acts as a critical immunomodulator, stimulating the chemotaxis of neutrophils, monocytes, and T-cells, and modulating the inflammatory response by neutralizing lipopolysaccharides (LPS). It provides researchers with a high-precision tool to study angiogenesis, the acceleration of re-epithelialization in wound healing, and the disruption of bacterial biofilms in persistent infection models.

Our LL-37 is synthesized in an ISO 9001:2015 certified and GMP-grade manufacturing environment. Utilizing advanced Solid-Phase Peptide Synthesis (SPPS) and high-resolution multi-stage HPLC purification, we achieve an ultra-high chemical purity of ≥99%. This meticulous production standard ensures the peptide is free from truncated sequences and residual synthesis reagents, guaranteeing the structural fidelity and biological activity required for sensitive research into host-defense mechanisms and cellular signaling.LL-37-Cathelicidin-–-Antimicrobial-peptide-Vial

Research Applications & Mechanisms

Antimicrobial & Biofilm Disruption

Investigating the peptide’s ability to permeate bacterial membranes and inhibit biofilm formation in various Gram-positive and Gram-negative experimental models.

Immunomodulation & Chemotaxis

Researching the pathways through which LL-37 recruits immune cells and interacts with Formyl Peptide Receptor 2 (FPR2) to study the regulation of the inflammatory cascade.

Wound Healing & Angiogenesis

Studying the stimulation of vascular endothelial growth factor (VEGF) and the promotion of keratinocyte migration to investigate accelerated tissue repair mechanisms.

LPS Neutralization

Exploring the capacity of LL-37 to bind and neutralize bacterial endotoxins, providing a model to study the mitigation of sepsis and systemic inflammatory responses.LL-37-Cathelicidin-–-Antimicrobial-peptide Mechanism-of-action

Technical Specifications

Parameter Laboratory Standard
Compound LL-37 (Human Cathelicidin)
Sequence Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser
Purity (HPLC) ≥99% (Pharmaceutical Grade)
Physical Appearance Fine, Smooth & Flat Lyophilized Cake
Molecular Weight 4493.3 Da
Concentration 5mg per vial
Solubility Soluble in Water / PBS / Bacteriostatic Water
Batch Control MS & HPLC Analysis Verified

Key Features & Quality Assurance

Pharmaceutical-Grade Lyophilization

Our proprietary vacuum-sealing process ensures the LL-37 powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the molecular stability of the complex 37-amino acid sequence during storage.

High-Fidelity Sequence Integrity

Every batch undergoes strict Mass Spectrometry (MS) to confirm the exact amino acid sequence, ensuring maximal receptor binding affinity and reproducible results in complex cellular assays.

Reconstitution & Storage

Reconstitution Guide

  • Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the LL-37 cake is at the base.

  • Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.

  • Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.

Storage Protocols

  • Long-term: Store at -20°C (Maintains potency for up to 24 months).

  • Short-term: Stable at 2–8°C for up to 3 months.

  • Post-Reconstitution: Store at 2–8°C and utilize within 10-14 days for optimal results.

Shipping & Documentation

  • Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the LL-37 peptide.

  • Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.

  • Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).

⚠️ Research Disclaimer

Product-Specific Safety Notice: This LL-37 is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.

Scientific Resources & References

🔍 Deep Dive Research

  • [Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency

  • [Immunity Study]: The Innate Frontier: Exploring LL-37 in Modern Infection and Healing Research

Weight 1.1 lbs
Dimensions 395 × 338 × 396 in
Specification

5mg*10vials

LL-37 FAQ

What is LL-37 and its primary significance in immunological research?
LL-37 is the only member of the cathelicidin family of antimicrobial peptides (AMPs) found in humans. In laboratory research, it is primarily investigated for its broad-spectrum antimicrobial activity, its ability to neutralize lipopolysaccharides (LPS), and its role as a signaling molecule in wound healing and innate immune response modulation.
Are there other names or chemical synonyms for LL-37?
LL-37 is scientifically identified as the Human Cathelicidin fragment, or by its 37-amino acid sequence starting with two Leucine residues (LL). It is often categorized as a “Host Defense Peptide” (HDP). Researchers typically search for LL-37 5mg vials to conduct specialized assays on bio-film disruption and cell signaling.
How does LL-37 interact with bacterial membranes in biochemical studies?
In scientific models, LL-37 exhibits an alpha-helical, amphipathic structure that allows it to bind and disrupt negatively charged bacterial membranes. Beyond direct killing, researchers study its ability to recruit immune cells (chemotaxis) and its complex role in both pro-inflammatory and anti-inflammatory pathways.
What purity level is guaranteed for your LL-37 5mg research vials?
We provide LL-37 with a verified purity of >=99% as confirmed by HPLC and Mass Spectrometry (MS) testing. As a specialized manufacturer in China, we ensure that our LL-37 5mg vials are free from truncated sequences and residual synthesis reagents, ensuring the high-fidelity results required for sensitive immune assays.
What are the optimal storage conditions for LL-37 5mg lyophilized powder?
To maintain maximum biological activity, LL-37 should be stored at -20°C for long-term stability. For short-term laboratory use, it can be kept at 2-8°C. We recommend avoiding repeated freeze-thaw cycles after reconstitution to preserve the peptide’s structural integrity.
Where is the best source to buy high-purity LL-37 5mg for laboratory use?
You can buy lab-certified LL-37 directly through our secure platform. We offer factory-direct pricing and reliable international shipping, serving as a premier supplier for biotech firms and academic research institutions looking for consistent quality in host defense peptides.
Do you offer wholesale pricing for bulk LL-37 5mg orders?
Yes, we provide competitive tiered pricing and significant discounts for bulk purchases of LL-37 5mg vials. Our large-scale production capacity allows us to support both small-scale pilot studies and large-scale distribution needs with the best cost-to-quality ratio.
What is your shipping and reshipment policy for international LL-37 orders?
We provide tracked global shipping with a one-time free reshipment guarantee. If your LL-37 order is lost or intercepted by customs during transit, we will reship the package at no extra cost, ensuring a secure and uninterrupted supply chain for your research.
Is LL-37 intended for human treatment of infections or as a supplement?
No. LL-37 is sold strictly as a Laboratory Research Chemical. It is not a drug, food, or supplement and is not intended for human or veterinary administration. It must be handled only by qualified personnel in a controlled laboratory environment.
Does every batch of LL-37 5mg come with a Certificate of Analysis (COA)?
Absolutely. Every shipment of LL-37 5mg is accompanied by a batch-specific COA. This document provides detailed analytical data on the 99%+ purity and molecular identity, ensuring the transparency and reproducibility required for peer-reviewed scientific research.

1 review for LL-37 (Cathelicidin) – Antimicrobial peptide 5mg

  1. Rated 5 out of 5

    mohame –

    Service was fine.

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