FOX04-DRI
FOXO4-DRI (FOXO4-D-Retro-Inverso) is a high-purity synthetic peptide designed as a potent Senolytic agent. In the field of advanced aging research and regenerative medicine, FOXO4-DRI is distinguished by its unique ability to selectively induce apoptosis (programmed cell death) in senescent cells—often referred to as “zombie cells.” It functions by competitively inhibiting the interaction between the FOXO4 transcription factor and the p53 tumor suppressor protein. By displacing p53 from the nucleus of senescent cells, FOXO4-DRI allows p53 to trigger mitochondrial-mediated apoptosis, effectively clearing damaged cells without harming healthy tissue. This provides researchers with a groundbreaking experimental model to investigate systemic rejuvenation, the reversal of age-related tissue dysfunction, and the molecular mechanisms of life extension.
Our FOXO4-DRI is synthesized in an ISO 9001:2015 certified environment utilizing advanced D-Retro-Inverso (DRI) peptide technology. This DRI modification—using D-amino acids in a reversed sequence—significantly enhances the peptide’s stability and resistance to proteolytic degradation (proteolysis), ensuring a much longer biological half-life than standard L-peptides. We achieve an ultra-high chemical purity of ≥99%, verified by HPLC and Mass Spectrometry (MS).
Research Applications & Mechanisms
Targeted Senolysis & Apoptosis Induction
Investigating the disruption of the p53-FOXO4 complex to study the selective clearance of senescent cell populations in aging models.
Tissue Regeneration & Frailty Reversal
Researching the mechanisms through which the removal of senescent cells promotes the recovery of hair growth, muscle mass, and organ function in research designs.
DNA Damage Response & Cellular Longevity
Studying the influence of FOXO4-DRI on the systemic inflammatory profile (SASP – Senescence-Associated Secretory Phenotype) and its role in investigating cellular health-span.
Metabolic & Physical Performance Research
Exploring the impact of senolytic therapy on cardiovascular health and overall physical endurance in experimental gerontology studies.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | FOXO4-DRI (D-Retro-Inverso) |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Structure | D-Amino Acid Modified Sequence |
| Molecular Weight | ~5358.1 Da |
| Concentrations | Available in 2mg / 10mg vials |
| Solubility | Soluble in PBS / Water / Bacteriostatic Water |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Advanced Lyophilization Stability
Our proprietary vacuum-sealing process ensures the FOXO4-DRI powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure protects the complex peptide sequence during long-term storage and ensures rapid reconstitution.
DRI-Technology for Enhanced Potency
The D-Retro-Inverso modification ensures that the peptide is not recognized or broken down by standard proteases in the research model, providing superior bioavailability and consistent experimental outcomes.
Reconstitution & Storage
Reconstitution Guide
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Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the FOXO4-DRI cake is at the base.
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Solvent: Reconstitute with Sterile Water or PBS.
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store at 2–8°C and utilize within 7-10 days for optimal results.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the FOXO4-DRI peptide.
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Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This FOXO4-DRI is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
- Structural, chemical, and peptide-related data for FOXO4-DRI (Forkhead box O4–D-retro-inverso peptide) can be explored via PubChem.
- ScienceDirect: Peptide Inhibitors Targeting FOXO4-p53 Interactions and Inducing Senescent Cancer Cell-specific Apoptosis.
🔍 Deep Dive Research
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[Technical Guide]: Understanding D-Retro-Inverso Peptides: Stability and Research Potency
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[Senolytic Study]: Clearing the Path: The Science of FOXO4-DRI in Longevity Research
mchosting –
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