Overview
Cortagen (scientifically identified by the amino acid sequence Ala-Glu-Asp-Pro or AEDP) is a high-purity synthetic tetrapeptide. In the landscape of advanced neuroscience and regenerative gerontology, Cortagen is recognized as a tissue-specific bioregulator for the central nervous system. Its primary mechanism of action involves the regulation of gene expression and protein synthesis within the neurons of the cerebral cortex. It provides researchers with a high-precision experimental model to investigate the restoration of synaptic plasticity, the mitigation of neuro-inflammatory responses, and the promotion of structural integrity in damaged neural tissues. Cortagen is widely utilized in studies focusing on age-related cognitive decline and the molecular pathways of neuroprotection.
Our Cortagen (AEDP) is synthesized in an ISO 9001:2015 certified environment utilizing high-resolution Solid-Phase Peptide Synthesis (SPPS). We achieve an ultra-high chemical purity of ≥99%, verified by HPLC and Mass Spectrometry (MS). This rigorous production standard ensures the tetrapeptide is free from truncated sequences and residual synthesis reagents, guaranteeing the consistency and structural fidelity required for sensitive neurological assays and longitudinal brain health research.
Research Applications & Mechanisms
Neuroprotection & Neuronal Survival
Investigating the mechanisms through which Cortagen protects cerebral neurons from oxidative stress and experimental neurotoxicity.
Synaptic Plasticity & Cognitive Function
Researching the influence of AEDP on the formation of new synaptic connections and investigating the molecular basis of memory and learning enhancement.
Modulation of Neuro-inflammation
Studying the peptide’s ability to normalize the systemic inflammatory profile within the brain and its role in mitigating neuro-degenerative signaling.
Gene Expression & Tissue Regeneration
Exploring the impact of Cortagen on DNA-peptide interactions to research the upregulation of tissue-specific proteins necessary for neural repair.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | Cortagen (AEDP) |
| Sequence | Ala-Glu-Asp-Pro |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | 430.41 g/mol |
| Concentration | Available in 20mg vials |
| Solubility | Highly Soluble in Water (Aqueous) / PBS |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the Cortagen powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the molecular stability of the tetrapeptide during long-term storage.
High-Fidelity Sequence Integrity
Every batch undergoes strict Mass Spectrometry (MS) to confirm the exact amino acid sequence (Ala-Glu-Asp-Pro), ensuring maximal target specificity and reproducible results in complex neuro-signaling research.
Reconstitution & Storage
Reconstitution Guide
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Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the Cortagen cake is at the base.
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Solvent: Reconstitute with Sterile Water or PBS.
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store at 2–8°C and utilize within 14-21 days for optimal results.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the Cortagen peptide.
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Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This Cortagen (AEDP) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
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National Center for Biotechnology Information (NCBI): Bioregulatory Peptides and Central Nervous System Research
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ScienceDirect (Elsevier): Peer-reviewed Research on Short Peptides and Neuroprotection
🔍 Deep Dive Research
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[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
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[Neurology Study]: Repairing the Network: The Science of Cortagen in Modern Brain Research
qoqiashvili –
Looks high purity.