Overview
Cibinetide (also identified as ARA290) is a high-purity synthetic 11-amino acid peptide derived from the three-dimensional structure of Erythropoietin (EPO). In the landscape of advanced neurobiology and immunology, Cibinetide is distinguished by its unique ability to bind selectively to the Innate Repair Receptor (IRR), a heterocomplex of the EPO receptor and the CD131 subunit. Unlike native EPO, Cibinetide does not stimulate erythropoiesis (red blood cell production), making it a refined experimental tool for investigating non-hematopoietic tissue protection. Its primary mechanism involves the systemic modulation of inflammatory signaling and the promotion of structural integrity in small-fiber nerves. It provides researchers with a high-precision model to investigate the reversal of neuropathic distress, the protection of tissue from ischemia, and the molecular pathways of immune system stabilization.
Our Cibinetide is synthesized in an ISO 9001:2015 certified environment utilizing high-precision Solid-Phase Peptide Synthesis (SPPS). We achieve an ultra-high chemical purity of ≥99%, verified by HPLC and Mass Spectrometry (MS). This rigorous production standard ensures the peptide is free from truncated sequences and residual chemical reagents, guaranteeing the consistency and biological fidelity required for research into small-fiber neuropathy and systemic cytoprotection.
Research Applications & Mechanisms
Small-Fiber Neuropathy & Neural Repair
Investigating the regeneration of small-fiber nerve endings and studying the peptide’s role in investigating the mitigation of allodynia and thermal hyperalgesia.
Selective IRR Activation & Anti-Inflammation
Researching the activation of the Innate Repair Receptor to study the suppression of pro-inflammatory cytokines (such as TNF-alpha and IL-6) in experimental models.
Cytoprotection & Ischemic Recovery
Studying the mechanisms through which Cibinetide protects critical organs and vascular tissues from injury induced by hypoxia or inflammation.
Metabolic & Glucose-Related Nerve Research
Exploring the influence of Cibinetide on insulin signaling and its role in investigating the preservation of nerve function in metabolic dysfunction models.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | Cibinetide (ARA290) |
| Sequence | Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-Cys |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | 1257.4 Da |
| Concentrations | Available in 10mg / 16mg vials |
| Solubility | Highly Soluble in Water (Aqueous) / PBS |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the Cibinetide powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the molecular stability of the 11-peptide chain during storage.
Non-Erythropoietic Selectivity Verified
Every batch is synthesized to ensure zero interaction with the homodimeric EPO receptor, guaranteeing that research outcomes are purely a result of IRR activation without impacting hematocrit levels.
Reconstitution & Storage
Reconstitution Guide
-
Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the Cibinetide cake is at the base.
-
Solvent: Reconstitute with Sterile Water or PBS.
-
Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
-
Long-term: Store at -20°C (Maintains potency for up to 24 months).
-
Short-term: Stable at 2–8°C for up to 3 months.
-
Post-Reconstitution: Store at 2–8°C and utilize within 10-14 days for optimal results.
Shipping & Documentation
-
Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the Cibinetide peptide.
-
Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
-
Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This Cibinetide (ARA290) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
-
National Center for Biotechnology Information (NCBI): Cibinetide Protects Isolated Human Islets in a Stressful Environment and Improves Engraftment in the Perspective of Intra Portal Islet Transplantation.
-
ScienceDirect (Elsevier): The non-erythropoietic analogue cibinetide inhibits osteoclastogenesis in vitro and increases bone density in mice
🔍 Deep Dive Research
-
[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
-
[Neurobiology Study]: The Innate Repair Pathway: Exploring ARA290 in Modern Neural Research
knine –
Good experience overall.