EPO (Erythropoietin)
EPO (Erythropoietin) is a high-purity, recombinant glycoprotein hormone that serves as the primary regulator of erythropoiesis (the production of red blood cells) in mammals. In advanced physiological and hematological research, EPO is distinguished by its ability to bind to the erythropoietin receptor (EpoR) on erythrooid progenitor cells in the bone marrow, stimulating their proliferation and differentiation. Beyond its hematopoietic role, emerging research highlights EPO’s potent cytoprotective and anti-apoptotic effects in non-hematopoietic tissues, particularly within the central nervous system and cardiovascular structures. This provides researchers with a robust experimental model to investigate cellular responses to hypoxia, oxygen transport dynamics, and systemic metabolic adaptation.
Our EPO is synthesized in an ISO 9001:2015 certified environment utilizing advanced recombinant DNA technology in mammalian cell lines (e.g., CHO cells) to ensure proper glycosylation patterns, which are essential for biological activity and stability. We achieve a superior purity level of ≥99%, verified by HPLC and SDS-PAGE. Each vial is standardized to deliver precisely 3000iu of biological activity, guaranteeing the consistency required for high-fidelity studies into oxygen homeostasis and tissue regeneration.
Research Applications & Mechanisms
Erythropoiesis & Hematological Regulation
Investigating the upregulation of hemoglobin synthesis and the acceleration of reticulocyte maturation in experimental blood-disorder models.
Hypoxia Signaling & Oxygen Homeostasis
Researching the interplay between EPO and Hypoxia-Inducible Factors (HIF) to study cellular adaptation to low-oxygen environments.
Neuroprotection & Ischemic Recovery
Studying the mechanisms through which EPO signaling mitigates neuronal apoptosis and promotes axonal integrity in research models of neurodegeneration or stroke.
Cardiovascular & Endothelial Stability
Exploring the influence of EPO on angiogenesis (new blood vessel formation) and the protection of vascular endothelial cells from oxidative stress.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | Recombinant Human Erythropoietin (rhEPO) |
| Molecular Weight | ~30,400 Da (including glycosylation) |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, White & Flat Lyophilized Cake |
| Activity Level | 3000iu per vial |
| Solubility | Highly Soluble in Water (Aqueous) / 0.9% Normal Saline |
| Batch Control | Biological Assay & Potency Verified |
Key Features & Quality Assurance
Advanced Glycoprotein Stability
Our proprietary vacuum-sealing process ensures the EPO powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure protects the complex 165-amino acid glycosylated chain from degradation during long-term storage.
Recombinant Biological Fidelity
By utilizing mammalian expression systems, our EPO retains the natural sialic acid content necessary for optimal receptor binding affinity and predictable physiological responses in research designs.
Reconstitution & Storage
Reconstitution Guide
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Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the EPO cake is at the base.
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Solvent: Reconstitute with Sterile Water or 0.9% Normal Saline.
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl very gently until the solution is clear. EPO is a sensitive glycoprotein and can be denatured by vigorous agitation.
Storage Protocols
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store at 2–8°C and utilize within 7 days for optimal stability.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the EPO hormone.
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Verified Quality: A batch-specific COA and biological activity reports are available for every order.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This EPO (Erythropoietin) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
- Comprehensive biological, structural, and glycoprotein hormone data for EPO (Erythropoietin) can be accessed via PubChem .
- Curated protein sequence, functional annotation, and receptor interaction data for EPO are available through UniProt.
🔍 Deep Dive Research
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[Technical Guide]: Handling Sensitive Glycoproteins: Best Practices for EPO Stability
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[Hematology Study]: Beyond the Red Cell: Exploring the Neuroprotective Potential of EPO
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