DSIP（Delta-Sleep Inducing Peptide）
DSIP (Delta-Sleep Inducing Peptide) is a high-purity synthetic nonapeptide (9 amino acids) originally isolated from the cerebral venous blood of rabbits in a state of induced sleep. In the landscape of advanced neuroscience and chronobiology, DSIP is distinguished by its unique ability to cross the blood-brain barrier and modulate the central nervous system’s electrical activity. Specifically, it promotes the occurrence of Delta-waves (slow-wave sleep), which are characteristic of the deepest and most regenerative stages of the sleep cycle. Beyond its somnogenic properties, DSIP functions as a potent physiological regulator, investigating the mitigation of oxidative stress, the normalization of blood pressure during distress, and the modulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis.
Our DSIP is synthesized in an ISO 9001:2015 certified environment utilizing high-precision Solid-Phase Peptide Synthesis (SPPS). We achieve an ultra-high chemical purity of ≥99%, verified by HPLC and Mass Spectrometry (MS). This rigorous production standard ensures the peptide is free from truncated sequences and residual synthesis reagents, guaranteeing the consistency and biological fidelity required for research into sleep architecture, neuroprotection, and hormonal homeostasis.
Research Applications & Mechanisms
Delta-Wave Induction & Sleep Architecture
Investigating the upregulation of slow-wave sleep (SWS) and studying its impact on cellular repair and cognitive recovery in research models.
HPA Axis Regulation & Stress Response
Researching the peptide’s role in modulating cortisol levels and investigating its ability to stabilize physiological parameters under experimental stress.
Neuroprotective & Antioxidant Properties
Studying the mechanisms through which DSIP reduces lipid peroxidation and protects neuronal membranes from oxidative damage in neurodegenerative models.
Circadian Rhythm & Endocrine Balance
Exploring the influence of DSIP on the secretion of LH and GH, and its role in investigating the synchronization of biological clocks.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | DSIP (Delta-Sleep Inducing Peptide) |
| Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | 848.81 Da |
| Concentrations | Available in 2mg, 5mg, 10mg vials |
| Solubility | Highly Soluble in Water (Aqueous) / Bacteriostatic Water |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the DSIP powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the molecular stability of the nonapeptide during storage.
High-Fidelity Sequence Integrity
Every batch undergoes strict Mass Spectrometry (MS) to confirm the exact amino acid sequence, ensuring maximal receptor binding affinity and reproducible results in complex neuro-endocrine signaling assays.
Reconstitution & Storage
Reconstitution Guide
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Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the DSIP cake is at the base.
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Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store at 2–8°C and utilize within 10-14 days for optimal results.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the DSIP peptide.
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Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This DSIP (Delta-Sleep Inducing Peptide) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
- Detailed chemical and structural information for DSIP is available via PubChem
- Protein-related annotations and sequence data associated with DSIP can be explored through
🔍 Deep Dive Research
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[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
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[Neuro Science Study]: Beyond Sleep: The Multi-Functional Role of DSIP in Modern Research
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