Overview
CJC-1295 (Without DAC), also widely recognized in the scientific community as Modified GRF 1-29 (Growth Hormone Releasing Factor), is a high-purity synthetic 29-amino acid peptide. It serves as a potent analog of the endogenous hormone GHRH. In the landscape of advanced endocrinology, the “No DAC” version is distinguished by its shorter biological half-life (approximately 30 minutes), which allows researchers to investigate the pulsatile release of growth hormone (GH) without the continuous, non-physiological elevation seen with long-acting analogs. By binding to GHRH receptors in the anterior pituitary, CJC-1295 (No DAC) triggers the natural secretion of GH, providing an ideal experimental model for studying the Hypothalamic-Pituitary-Somatotropic axis, nitrogen retention, and the molecular pathways of systemic tissue regeneration.
Our CJC-1295 (Without DAC) is synthesized in an ISO 9001:2015 certified environment utilizing high-precision Solid-Phase Peptide Synthesis (SPPS). We achieve an ultra-high chemical purity of ≥99%, verified by HPLC and Mass Spectrometry (MS). This ensures the peptide is free from truncated sequences and residual chemical reagents, guaranteeing the consistency and structural fidelity required for high-fidelity studies into cellular hypertrophy and metabolic signaling.
Research Applications & Mechanisms
Pulsatile Growth Hormone Secretion
Investigating the amplification of natural GH pulses to study the subsequent upregulation of Insulin-like Growth Factor 1 (IGF-1) in experimental models.
Protein Synthesis & Muscle Tissue Repair
Researching the mechanisms through which GHRH analogs promote nitrogen retention and accelerate the repair of skeletal muscle and connective tissues.
Lipid Metabolism & Adipocyte Signaling
Studying the influence of CJC-1295 on fatty acid mobilization and its role in investigating the reduction of visceral adipose tissue in metabolic research.
Deep Sleep & Circadian Rhythm
Exploring the interaction between GH secretion and slow-wave sleep (SWS) patterns to study the neuro-endocrine benefits of optimized GH pulses.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | CJC-1295 (Without DAC / Mod GRF 1-29) |
| Sequence | Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Fine, Smooth & Flat Lyophilized Cake |
| Molecular Weight | 3367.9 Da |
| Concentrations | Available in 2mg, 5mg, 10mg vials |
| Solubility | Highly Soluble in Water (Aqueous) / Bacteriostatic Water |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the CJC-1295 powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and maintains the molecular stability of the 29-amino acid chain during storage.
High-Fidelity Sequence Integrity
Every batch undergoes strict Mass Spectrometry (MS) to confirm the exact amino acid sequence, ensuring maximal receptor binding affinity and reproducible results in complex hormonal signaling assays.
Reconstitution & Storage
Reconstitution Guide
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Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the CJC-1295 cake is at the base.
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Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.
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Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is clear and transparent.
Storage Protocols
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Long-term: Store at -20°C (Maintains potency for up to 24 months).
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Short-term: Stable at 2–8°C for up to 3 months.
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Post-Reconstitution: Store at 2–8°C and utilize within 10-14 days for optimal results.
Shipping & Documentation
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Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the CJC-1295 (No DAC) peptide.
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Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
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Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This CJC-1295 (Without DAC) is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
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National Center for Biotechnology Information (NCBI): GHRH Analogs and Pulsatile Secretion Research
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ScienceDirect (Elsevier): Peer-reviewed Research on Mod GRF 1-29 and Metabolic Control
🔍 Deep Dive Research
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[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
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[Endocrine Study]: The Pulsatile Advantage: Why Mod GRF 1-29 Remains a Research Essential
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