AHK-CU (Copper Tripeptide-3)
AHK-Cu, also known as Copper Tripeptide-3, is a high-purity synthetic complex consisting of the tri-peptide L-Alanyl-L-Histidlyl-L-Lysine chelated with a copper (II) ion. While structurally similar to the well-known GHK-Cu, the specific amino acid sequence of AHK-Cu grants it unique biological affinities, particularly within vascular endothelial cells and dermal papilla cells. In the landscape of dermatological and regenerative research, AHK-Cu is an essential experimental tool for investigating the stimulation of hair follicle growth, the synthesis of type I collagen, and the regulation of vascular endothelial growth factor (VEGF). It provides researchers with a targeted model to study the reversal of follicular miniaturization and the enhancement of localized microcirculation.
Our AHK-Cu is synthesized in an ISO 9001:2015 certified environment using precision liquid-phase peptide synthesis and controlled chelation. We achieve an ultra-high chemical purity of ≥99%, ensuring a stable and potent complex. The product is characterized by its signature vibrant blue color and high aqueous solubility, offering the reliability and reproducibility required for high-fidelity cellular assays and tissue engineering studies.
Research Applications & Mechanisms
Hair Follicle Stimulation & Growth
Investigating the activation of dermal papilla cells and the peptide’s influence on the elongation of the hair shaft in experimental follicle models.
Endothelial Cell Proliferation
Researching the pathways through which AHK-Cu promotes the growth of vascular endothelial cells to study improved micro-vascularization.
Collagen & Extracellular Matrix (ECM) Synthesis
Studying the upregulation of fibroblast activity and the production of structural proteins to investigate tissue remodeling and skin integrity.
Anti-Apoptotic Effects in Dermal Tissue
Exploring the role of AHK-Cu in protecting dermal cells from oxidative stress and environmental damage to study cellular longevity.
Technical Specifications
| Parameter | Laboratory Standard |
| Compound | AHK-Cu (Copper Tripeptide-3) |
| Sequence | Ala-His-Lys (Complexed with Cu2+) |
| Purity (HPLC) | ≥99% (Pharmaceutical Grade) |
| Physical Appearance | Vibrant Blue, Smooth & Flat Lyophilized Cake |
| Molecular Weight | 388.9 g/mol |
| Concentration | 50mg per vial |
| Solubility | Highly Soluble in Water (Aqueous) / Bacteriostatic Water |
| Batch Control | MS & HPLC Analysis Verified |
Key Features & Quality Assurance
Pharmaceutical-Grade Lyophilization
Our proprietary vacuum-sealing process ensures the AHK-Cu powder surface is perfectly smooth, flat, and delicate. This uniform “cake” structure ensures rapid, clear reconstitution and protects the copper-peptide complex from premature degradation during storage.
Superior Chelation Stability
Our synthesis protocol ensures that the copper ions are securely bound to the AHK sequence, preventing ion dissociation and ensuring consistent bioactivity across all research applications.
Reconstitution & Storage
Reconstitution Guide
-
Preparation: Allow the vial to reach room temperature. Centrifuge for 30-60 seconds to ensure the AHK-Cu cake is at the base.
-
Solvent: Reconstitute with Sterile Water or Bacteriostatic Water.
-
Technique: Gently introduce the diluent against the vial wall. DO NOT SHAKE; swirl gently until the solution is a clear, transparent blue.
Storage Protocols
-
Long-term: Store at -20°C (Maintains potency for up to 24 months).
-
Short-term: Stable at 2–8°C for up to 3 months.
-
Post-Reconstitution: Store at 2–8°C and utilize within 14 days for optimal potency.
Shipping & Documentation
-
Global Logistics: Shipped in discreet, temperature-controlled packaging to maintain the structural integrity of the AHK-Cu complex.
-
Verified Quality: A batch-specific COA and HPLC/MS reports are available for every order.
-
Reshipment Policy: We provide a guaranteed reshipment policy for any lost or customs-intercepted orders (terms apply).
⚠️ Research Disclaimer
Product-Specific Safety Notice: This AHK-Cu is strictly for laboratory research and analytical purposes. It is NOT intended for human or veterinary administration. All research must be conducted by qualified professionals.
Scientific Resources & References
-
National Center for Biotechnology Information (NCBI): Compound Summary – AHK-Cu (Copper tripeptide: Ala-His-Lys complex)
-
PubMed – NIH: Research on AHK-Cu and copper peptides in skin regeneration and hair follicle biology
🔍 Deep Dive Research
-
[Technical Guide]: How to Reconstitute and Store Lyophilized Peptides for Maximum Potency
-
[Follicle Study]: Targeted Regeneration: The Role of AHK-Cu in Modern Hair Follicle Research
iceblazee –
Will order again.